US EPA

3044477 

Journal Article 

Antioxidant Potential and Iron Chelating Activity of Some Bioactive Compounds 

Babri, RA; Khokhar, I; Mahmud, S 

2015 

Yes 

Journal of the Chemical Society of Pakistan
ISSN: 0253-5106 

37 

3 

514-519 

WOS:000357683700016 

The antioxidant activity and metal chelating potential of S-(+)-carvone, R-(-)-carvone, p-cumenol, cuminyl alcohol, cuminal, 4-methoxycumene, p-cymene, gamma-terpinene and thymol were studied using DPPH assay, ABTS assay, FRAP test, reducing power assay and metal chelating assay. Phenols and gamma-terpinene were found to possess excellent antioxidant activity whereas cuminal, cuminyl alcohol and p-cymene showed weak activity. In contrast, the metal chelating assay proved cuminal, R-(-)-carvone, gamma-terpinene and cuminyl alcohol to be superior chelating agents as compared to other compounds and BHA. These results represent the first report on the antioxidant and iron chelating activities of R-(-)-carvone, p-cumenol, cuminyl alcohol, cuminal and 4-methoxycumene. The investigated compounds, which are commonly found in essential oils, show the potential to be used as natural antioxidants as well as chelating agents in chelation therapy for patients suffering from iron-overload. 

Antioxidant activity; iron chelating activity; p-cumenol; cuminal; 4-methoxycumene; carvone