US EPA

3044744 

Journal Article 

Percutaneous absorption and removal by the body fluids of 14C ethyl alcohol, 3H perhydrosqualene and 14C p-cymene 

Wepierre, J; Cohen, Y; Valette, G 

1968 

1 

European Journal of Pharmacology
ISSN: 0014-2999
EISSN: 1879-0712 

3 

1 

47-51 

English 

5654669 

10.1016/0014-2999(68)90047-2 

Percutaneous absorption of ethyl-alcohol (64175), perhydrosqualene (111013), and p-cymene (99876) was investigated. Male albino-mice were treated topically with 0.1 milliliter of radio labeled solutions of one of the test agents. In some tests with ethyl-alcohol and perhydrosqualene, the stratum corneum was removed before treatment. At selected times, the skin was removed and analyzed for radioactivity. Absorption rates were 10.5 and 0.12 nanomoles per square centimeter per minute for ethyl-alcohol and perhydrosqualene, respectively, for nonabraded skin. When the stratum corneum was removed, ethyl-alcohol penetration rate increased to 200 nanomoles per square centimeter per minute, but the rate for perhydrosqualene did not change. The penetration rate of p-cymene was 32 nanomoles per square centimeter per minute over 1 hour. The authors conclude that dermal absorption is affected by the epidermal barrier and the removal capacity of the blood. The liposolubility of the agent also affects its penetration through the epidermal stratum. 

Percutaneous absorption; 14C ethyl alcohol 3H perhydrosqualene; 14C p-cymene