Health & Environmental Research Online (HERO)


Print Feedback Export to File
3045408 
Journal Article 
Solubility of anti-inflammatory drug lornoxicam in ten different green solvents at different temperatures 
Shakeel, F; Haq, N; Alanazi, FK; Alsarra, IA 
2015 
Yes 
Journal of Molecular Liquids
ISSN: 0167-7322 
209 
280-283 
WOS:000359958500036 
In this work, the solubility of poorly water soluble anti-inflammatory drug lornoxicam (LOX) in ten different green solvents such as water, ethanol, 1-butanol, 2-butanol, ethylene glycol (EG), ethyl acetate (EA), isopropanol (IPA), propylene glycol (PG), polyethylene glycol-400 (PEG-400) and 2-(2-ethoxyethoxy) ethanol was measured at T = (298.15 to 323.15) K and p = 0.1 MPa using an isothermal method. The measured solubility data of LOX were correlated with Apelblat and Van't Hoff models with root mean square deviations in the range of 033 to 3.70%. The mole fraction solubility of LOX was observed highest in PEG-400 (8.55 x 10(-3)) followed by 2-(2- ethoxyethoxy) ethanol, EG, EA, PG, 2-butanol,1-butanol, IPA, ethanol and water at T=298.15 K. Thermodynamic analysis indicated an endothermic and spontaneous dissolution behavior of LOX in all green solvents. (C) 2015 Elsevier B.V. All rights reserved. 
Apelblat model; Green solvent; Lornoxicam; Solubility; Thermodynamics; Van't Hoff model