US EPA

3045580 

Book/Book Chapter 

Respiratory system 

Harkema, JR; Nikula, KJ; Haschek, WM 

2013 

Yes 

Academic Press 

Waltham, MA 

Haschek and Rousseaux's handbook of toxicologic pathology 

III 

1935–2003 

English 

10.1016/B978-0-12-415759-0.00051-0 

http://www.sciencedirect.com/science/article/pii/B9780124157590000510
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is a chapter of 3042124 Haschek and Rousseaux's handbook of toxicologic pathology

The respiratory tract is a complex organ system both macroscopically and microscopically, with many different functions and cell types localized throughout the nasopharyngeal, tracheobronchial, and pulmonary segments. Exposure to xenobiotics occurs via inhalation and via the blood following ingestion, dermal exposure, or parenteral administration. Xenobiotics vary from particles of variable size to gases to plant toxins, thus dosimetry and site of injury are critical in interpreting the response to injury. In addition, species differences must be considered in interpretation of data to be used in risk assessment. In naturally occurring disease, since the pulmonary response to injury is often non-specific, it is important to consider the gross distribution of pulmonary lesions and to use detailed history and ancillary test results in conjunction with histological evaluation to determine potential etiologic agents. 

3rd 

Haschek, W; Rousseaux, C; Wallig, M 

Systems Toxicologic Pathology 

9780124157590