Headache response to nitrate in patients with coronary artery disease and systolic heart failure | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

3045919

Reference Type

Journal Article

Subtype

Letter

Title

Headache response to nitrate in patients with coronary artery disease and systolic heart failure

Author(s)

Sivri, N; Tekin, G; Erbay, AR; Yalta, K; Senen, K; Gür, M; Yetkin, E

Year

2012

Is Peer Reviewed?

Yes

Journal

International Journal of Cardiology
ISSN: 0167-5273
EISSN: 1874-1754

Volume

158

Issue

Page Numbers

453-454

Language

English

PMID

22633669

DOI

10.1016/j.ijcard.2012.05.025

Web of Science Id

WOS:000306123800036

URL

http://www.internationaljournalofcardiology.com/article/S0167-5273(12)00636-5/abstract
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Abstract

Nitrates by inducing venodilatation result in decreases of venous return to heart, reduction of filling pressure and heart volume and subsequently myocardial wall stress and myocardial oxygen demand. Headache is the most common side effect of nitrate ranging from 2% to 73% depending on the clinical state in literature [1–3]. Although headache rate has been reported separately almost in every clinical spectrum of cardiovascular diseases in which nitrate therapy is indicated, headache comparison has been performed in limited studies [4].We aimed to assess and compare the headache response rate in patients with coronary artery disease and patients with systolic heart failure of ischemic etiology.