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3046723 
Journal Article 
EFFECT OF PROPYLENE-GLYCOL ON SUBCUTANEOUS ABSORPTION OF A BENZIMIDAZOLE HYDROCHLORIDE 
Yu, CD; Kent, JS 
1982 
Yes 
Journal of Pharmaceutical Sciences
ISSN: 0022-3549
EISSN: 1520-6017 
IPA/82/494042 
71 
4 
476-478 
English 
7086668 
WOS:A1982NL71100032 
IPA COPYRIGHT: ASHP The effect of propylene glycol on the SC absorption of an ionic drug, 5(6)-isobutylsulfinyl-2-carbomethoxyaminobenzimidazole HCl (I), was investigated in cows. The absorption rate of I was higher for formulations containing propylene glycol than for aqueous solution, with a combination vehicle showing intermediate absorption rate values. These results are in direct contrast to results with nonionic drugs. The solubility effects of propylene glycol on ionic species is discussed to explain the contrast.