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3047161 
Journal Article 
RESPONSE OF DOGS TO SUBCUTANEOUS INJECTIONS OF VARIOUS CONCENTRATIONS OF PROPYLENE-GLYCOL WITH WATER 
Brown, JM; Kasson, CW 
1984 
Yes 
American Journal of Veterinary Research
ISSN: 0002-9645
EISSN: 1943-5681 
45 
1 
83-86 
English 
6703460 
WOS:A1984RX69300014 
Each of 85 dogs was injected, subcutaneously, with 5 different mixtures of propylene glycol (PG) and aqueous vehicles. Each dog was observed for immediate (within 15 minutes) and delayed (at 24, 48, and 72 hours) reactions. The reactions were classified as none, mild, moderate, and severe for the different observation periods. The study indicated that a mixture containing between 20% and 50% PG caused the fewest immediate reactions and that the number of delayed reactions increased as the proportion of PG in the solutions increased. Viscosity of the mixture also should be considered when selecting a vehicle.