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3047480 
Journal Article 
Clinical evaluation of an HP-guar gellable lubricant eye drop for the relief of dryness of the eye 
Christensen, MT; Cohen, S; Rinehart, J; Akers, F; Pemberton, B; Bloomenstein, M; Lesher, M; Kaplan, D; Meadows, D; Meuse, P; Hearn, C; Stein, JM 
2004 
1 
Current Eye Research
ISSN: 0271-3683
EISSN: 1460-2202 
28 
1 
55-62 
English 
14704914 
WOS:000188665100008 
PURPOSE: To evaluate the efficacy of a new lubricant eye drop containing polyethylene glycol 400 and propylene glycol demulcents with hydroxypropyl-guar as a gelling agent (Test Product) to a system with carboxymethylcellulose (Control Product) for reducing dry eye signs and symptoms.

METHODS: Eighty-seven dry eye volunteers were enrolled at seven sites for this six-week, concurrently controlled, double-masked clinical study.

RESULTS: The Test Product significantly reduced conjunctival staining (p = 0.025) and temporal corneal staining (p = 0.024) compared to the Control. The Test Product also significantly reduced symptoms of dryness in the morning and evening, compared to the Control (p = 0.015 and p = 0.023, respectively). Subjects in the Test treatment group reported lower frequencies of foreign body sensation and felt their eyes were "refreshed longer" compared to those in the Control group (p = 0.033 and p = 0.037, respectively).

CONCLUSIONS: The Test Product was more effective at reducing both the signs and symptoms of dry eye compared to the carboxymethylcellulose containing Control. 
artificial tear; carboxymethylcellulose; dry eye; hydroxypropyl-guar; propylene glycol