Nephrogenic systemic fibrosis: a systemic fibrosing disease resulting from gadolinium exposure | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

3054131

Reference Type

Journal Article

Subtype

Review

Title

Nephrogenic systemic fibrosis: a systemic fibrosing disease resulting from gadolinium exposure

Author(s)

Bernstein, EJ; Schmidt-Lauber, C; Kay, J

Year

2012

Is Peer Reviewed?

Yes

Journal

Best Practice & Research Clinical Rheumatology
ISSN: 1521-6942
EISSN: 1532-1770

Volume

Issue

Page Numbers

489-503

Language

English

PMID

23040363

DOI

10.1016/j.berh.2012.07.008

Web of Science Id

WOS:000310124600007

URL

http://www.bprclinrheum.com/article/S1521-6942(12)00071-X/abstract
Exit

Abstract

Nephrogenic systemic fibrosis (NSF) is an iatrogenic fibrosing disorder that primarily affects individuals with chronic kidney disease (CKD) following exposure to gadolinium-based contrast agents (GBCAs) during imaging procedures. NSF is characterised by skin thickening, tethering and hyperpigmentation; flexion contractures of joints; and extracutaneous fibrosis. This article reviews the history, clinical manifestations, epidemiology, histopathology and pathophysiology of this disabling disease.