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Citation
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HERO ID
3056080
Reference Type
Journal Article
Title
Gadolinium chloride toxicity in the mouse
Author(s)
Spencer, A; Wilson, S; Harpur, E
Year
1998
Is Peer Reviewed?
Yes
Journal
Human & Experimental Toxicology
ISSN:
0960-3271
EISSN:
1477-0903
Volume
17
Issue
11
Page Numbers
633-637
Language
English
PMID
9865421
Abstract
1. Groups of five male and five female CD-1 mice received a single intravenous injection of gadolinium chloride at dosages of 0 (saline control), 0.05, 0.1 and 0.2 mmol/ kg. All mice were necropsied 48 h post dose. 2. Plasma analysis showed increases in concentrations of lactate dehydrogenase (both sexes), aspartate aminotransferase and alanine aminotransferase (females only) in the 0.2 mmol/kg group. Cholesterol was elevated at all dosages in both sexes whilst globulin was raised in both sexes at 0.1 and 0.2 mmol/kg. 3. Histological lesions were present at all dosages and increased in severity in a dose-related fashion. The most common lesions were: mineral emboli in capillaries, accumulation of mineral in the mononuclear phagocytic system, hepatocellular necrosis, and lymphoid depletion, necrosis and mineralisation in the spleen. 4. Such observations are similar to those in rats given gadolinium chloride and should be assessed when evaluating the toxicological profile of gadolinium containing compounds being developed for nuclear magnetic resonance imaging.
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