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3056506 
Journal Article 
Letter 
Acute deterioration of myasthenia gravis after intravenous administration of gadolinium-DTPA 
Nordenbo, AM; Somnier, FE 
1992 
1 
The Lancet
ISSN: 0140-6736
EISSN: 1474-547X 
IPA/93/1021042 
340 
8828 
1168 
English 
1359250 
IPA COPYRIGHT: ASHP Acute deterioration of myasthenia gravis after a single intravenous administration of 0.2 ml/kg of gadopentetate dimeglumine (Magnevist) is reported in a 59-yr-old man who had magnetic resonance imaging of the brain with gadopentetate dimeglumine as contrast medium. The patient immediately had general weakness of skeletal muscles, including difficulties in walking and raising both arms. During the following month the condition rapidly deteriorated with development of features characteristic of myasthenia gravis. The neuromuscular disease was treated with pyridostigmine, prednisone, and plasma exchanges, resulting in rapid improvement.