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HERO ID
3058136
Reference Type
Journal Article
Title
Locally synthesized HSP27 in hepatocytes: Is it possibly a novel strategy against human liver ischemia/reperfusion injury?
Author(s)
Ye, SY; Wu, J; Zhang, J; Zheng, SS
Year
2011
Is Peer Reviewed?
1
Journal
Medical Hypotheses
ISSN:
0306-9877
EISSN:
1532-2777
Volume
76
Issue
2
Page Numbers
296-298
Language
English
PMID
21067867
DOI
10.1016/j.mehy.2010.10.028
Web of Science Id
WOS:000287677400046
Abstract
Ischemia/reperfusion injury (IRI) is a common complication after liver surgery. Approximately 10% of grafts lose function in the early stage after liver transplantation. However, there is no effective way against IRI yet. Heat shock protein 27 (HSP27), a member of the heat shock protein families, is recognized as a protective factor against liver IRI recently. Studies showed that HSP27 can lessen the induction of proinflammatory messenger, reduce neutrophil infiltration, decrease apoptosis (caspase 3 fragmentation and DNA laddering), and reduce disruption of filamentous actin. In addition, Kupffer cells inhibitor- gadolinium chloride can reduce lipid peroxidation and promote hepatocytes regeneration. Herein, we hypothesize that transfecting liver with HSP27 gene accompanied by gadolinium chloride might be a potentially novel treatment against IRI. Compared to passive defense, we firstly suggest positive protection against ischemia/reperfusion injury by hepatocytes automatically. (C) 2010 Elsevier Ltd. All rights reserved.
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