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3062819 
Technical Report 
Adrenal carcinoma in child with history of fetal alcohol syndrome 
Hornstein, L; Crowe, C; Gruppo, R 
1977 
PESTAB/78/0905 
8051 
8051 
PESTAB. A 13 yr old child is described with features of the fetal alcohol syndrome who had an adrenal carcinoma. The girl was born to a 39 yr old chronic alcoholic. Strabismus and slow motor and mental development were noted in the child. At 21 mo of age there was facial asymmetry, hypertelorism, epicanthal folds, alternating esotropia, and questionable hemihypertrophy of the left. A cavernous hemangioma was noted in the occipital area. At 12 yr 11 mo the child was diagnosed as having a malignant tumor, which was traced to a non-secreting adrenocortical carcinoma with metastases to bone, lungs, liver, abdominal nodes, and bone marrow. She was treated with mitotane (o,p'-DDD) but died suddenly on day 41 of therapy. The question of whether intrauterine exposure to alcohol could lead not only to the fetal alcohol syndrome but also to malignant tumors must be considered.