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3063438 
Journal Article 
Toxicological and pharmacological effects of gadolinium and samarium chlorides 
Haley, TJ; Raymond, K; Komesu, N; Upham, HC 
1961 
Yes 
British Journal of Pharmacology and Chemotherapy
ISSN: 0366-0826 
17 
526-532 
English 
13903826 
A study has been made of the toxicology and pharmacology of gadolinium and samarium chlorides. The symptoms of acute toxicity following intraperitoneal injection are described. The chronic oral ingestion of both chemicals for 12 weeks produced no effects on growth or the blood picture, and only the male rats receiving gadolinium chloride showed liver damage. The pharmacological responses to both chemicals were mainly depressant on all systems studied, and death was associated with cardiovascular collapse coupled with respiratory paralysis. The greatest damage seen was on abraded skin, where non-healing ulcers were produced by both chemicals, whereas irritation of intact skin and ocular tissues was only transient in nature.