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3064145 
Journal Article 
Abstract 
Alterations in liver microsomal metabolism of parathion caused by chronic administration of dilantin, chloroquine, or DDE 
Davis, JE; Cranmer, MF; Peoples, A 
1971 
1 
Toxicology and Applied Pharmacology
ISSN: 0041-008X
EISSN: 1096-0333 
19 
2 
399-400 
English 
is part of a larger document 3479581 Abstracts of papers for the Tenth Annual Meeting of the Society of Toxicology, Washington, D.C. March 7–11, 1971
Monkeys and rats were fed dilantin, chloroquine, or DDE in order to assess the effects of these compounds on liver microsomal metabolism of parathion and the inductive mechanisms involved. Dilantin, chloroquine, or a combination of both drugs was fed to male squirrel monkeys for 1 mo and to female rats for 1 wk. DDE was added to the food of female rats for 18 mo. Liver microsomes were isolated and were incubated with parathion and a NADPH generating system. The parathion metabolites produced were analyzed by gas chromatography. Dilantin increased the cytochrome P-450 level and the metabolism of parathion in monkey liver microsomes, but had no significant effect on either of these parameters in rats. Chloroquine treatment of monkeys and rats did not affect the cytochrome P-450 level in, or parathion metabolism by, the liver microsomes of either species. The feeding of dilantin and chloroquine affected neither the cytochrome P-450 level in, nor the parathion metabolism by, rat liver microsomes. DDE administration greatly increased the liver microsomal metabolism of parathion but had no effect on the cytochrome P-450 level. 
Tenth Annual Meeting of the Society of Toxicology 
Washington, D.C. 
March 7–11, 1971