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Citation
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HERO ID
3064600
Reference Type
Technical Report
Title
Modification of toxic effects of DMBA by DDT and DDE
Author(s)
Turusov, VS; Chemeris, GY
Year
1976
Is Peer Reviewed?
Yes
Journal
Chemico-Biological Interactions
ISSN:
0009-2797
EISSN:
1872-7786
Report Number
PESTAB/77/0145
Volume
Biol
Issue
3
Page Numbers
295-298; 1976
Language
English
DOI
10.1016/0009-2797(76)90155-1
Abstract
PESTAB. DDT and DDE are known liver enzyme inducers; their ability to prevent the adrenolytic and lethal effects of DMBA (dimethylbenzanthracene) was examined. White random-bred female rats were given DDT in sunflower oil by stomach tube at 1, 10, or 100 mg/kg body weight on each of three successive days. In one experiment DMBA was given at 30 mg per rat on the day after the last DDT administration. In another experiment DDE was given at 100 mg/kg and 30 mg of DMBA was given 1, 2, 3, 4, 6, 8, or 10 days thereafter. In one group the DDE was given 2 hr after DMBA administration. All the rats given DMBA alone died within three days. Only one rat in the lowest DDT dosage group died; all others given DDT survived. Diffuse or focal adrenal necrosis was weakened in the case of DDT pretreatment. Single treatment with DDE 1 to 8 days before DMBA administration considerably reduced mortality; 2/34 rats treated in this manner died, compared to 9/10 rats given DMBA alone and 3/5 given DDE 2 hr after DMBA. Adrenal weight increased relative to liver weight in DMBA-treated rats; this effect was reduced by DDT or DDE administration. The degree of structural damage in the DDE-treated animals was similar to that in the group given DMBA alone.
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