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3064600 
Technical Report 
Modification of toxic effects of DMBA by DDT and DDE 
Turusov, VS; Chemeris, GY 
1976 
Yes 
Chemico-Biological Interactions
ISSN: 0009-2797
EISSN: 1872-7786 
PESTAB/77/0145 
Biol 
3 
295-298; 1976 
English 
PESTAB. DDT and DDE are known liver enzyme inducers; their ability to prevent the adrenolytic and lethal effects of DMBA (dimethylbenzanthracene) was examined. White random-bred female rats were given DDT in sunflower oil by stomach tube at 1, 10, or 100 mg/kg body weight on each of three successive days. In one experiment DMBA was given at 30 mg per rat on the day after the last DDT administration. In another experiment DDE was given at 100 mg/kg and 30 mg of DMBA was given 1, 2, 3, 4, 6, 8, or 10 days thereafter. In one group the DDE was given 2 hr after DMBA administration. All the rats given DMBA alone died within three days. Only one rat in the lowest DDT dosage group died; all others given DDT survived. Diffuse or focal adrenal necrosis was weakened in the case of DDT pretreatment. Single treatment with DDE 1 to 8 days before DMBA administration considerably reduced mortality; 2/34 rats treated in this manner died, compared to 9/10 rats given DMBA alone and 3/5 given DDE 2 hr after DMBA. Adrenal weight increased relative to liver weight in DMBA-treated rats; this effect was reduced by DDT or DDE administration. The degree of structural damage in the DDE-treated animals was similar to that in the group given DMBA alone.