Health & Environmental Research Online (HERO)


Print Feedback Export to File
3068436 
Journal Article 
Review 
Is diacetyl a respiratory sensitizer? A reconsideration using QSAR, QMM, and competition experiments 
Dworak, JJ; Roberts, DW; Calter, MA; Fields, CA; Borak, J 
2013 
Yes 
Chemical Research in Toxicology
ISSN: 0893-228X
EISSN: 1520-5010 
26 
5 
631-633 
English 
23593960 
Concerns have been raised that diacetyl (DA) might be a respiratory sensitizer based on its LUMO energy similar to that of the respiratory allergen toluene-2,4-diisocyanate (TDI) and results of a local lymph node assay (LLNA) that reported an EC3 of 1.9%. To better understand the concerns, we performed a systematic literature review and experimental competition reactions between DA and TDI. The experimental evidence demonstrates that DA is at least 400-fold less reactive than TDI. The literature review finds evidence that the EC3 for DA is actually >11%. We conclude that DA is unlikely to have significant respiratory sensitization potential.