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3070369 
Journal Article 
ADDITIVE TOXICITIES OF ANILINES, NITROBENZENES, PHENOLS, AND PHTHALATES ON PHOTOBACTERIUM Q67 
Ge, H; Mo, L; Zhu, Zhu 
2015 
1 
Fresenius Environmental Bulletin
ISSN: 1018-4619
EISSN: 1610-2304 
24 
3A 
920-926 
English 
WOS:000361782200009 
The effects of four anilines, two nitrobenzenes, four phenols, two phthalates individually, and their mixtures on the bioluminescence inhibition of Vibrio qinghaiensis sp.-Q67 were studied by using microplate toxicity analysis. The toxicity of a substituted benzene will increase when introducing -NO2, -NH2, or -CH3 into the molecule. The mixtures of these substituted benzenes were built according to uniform design concentration ratio method. The pEC(50) of mixtures had a monotonically increasing relationship with the concentration proportion of the component having the most toxicity in the mixtures. Observed mixture toxicities were compared with predictions calculated by concentration addition (CA) and independent action (IA) models. CA and IA made equally good predictions for the mixture toxicities, irrespective of mixture ratios and effect levels. The mixture of the anilines, nitrobenzenes, phenols, and phthalates presented additive toxicity on photobacterium Q67. 
Concentration addition; independent action; uniform design; microplate toxicity analysis; Vibrio qinghaiensis