US EPA

3077598 

Journal Article 

Further observations of cardiovascular effects of pentaerythritol tetranitrate in animals and man 

Winsor, T; Scott, CC 

1955 

Yes 

American Heart Journal
ISSN: 0002-8703
EISSN: 1097-6744 

49 

3 

414-427 

English 

14349856 

10.1016/0002-8703(55)90035-1 

Previous studies on pentaerythritol tetranitrate for the prophylaxis of angina pectoris have shown that the oral administration of this agent increases exercise tolerance, decreases nitroglycerine requirement, and has a normalizing effect on the negative S-T segment shifts which occur in patients with angina pectoris and coronary insufficiency. The present study was carried out to determine if pentaerythritol tetranitrate (PETN) (1) dilates the coronary arties in a manner similar to nitroglycerine, (2) produces peripheral arterial vasodilation, (3) is effective sublingually since this route might allow more rapid absorption, (4) is absorbed though the pulmonary route, and (5) compares favorably in effectiveness with other nitrates in the prophylaxis of angina pectoris.