US EPA

3085109 

Journal Article 

Histological characteristics of mesothelioma associated with asbestos 

Churg, J; Rosen, SH; Moolten, S 

1965 

Yes 

Annals of the New York Academy of Sciences
ISSN: 0077-8923
EISSN: 1749-6632 

NIOSH/00192616 

132 

1 

614-622 

English 

4222863 

The histological features of thirty cases of mesothelioma with confirmed asbestosis were reviewed and discussed. Insulation workers exposed to asbestos (1332214) accounted for 11 cases. Seven were identified from a series of 26 consecutive asbestosis cases found at autopsy, and 12 were found from patients admitted to hospital for mesothelioma. Eight of the 30 had no known asbestos exposure or pulmonary asbestos bodies. Thirteen cases were pleural, and 17 were peritoneal mesotheliomas. On cytologic examination, epithelial cells were found to occur in cuboidal forms with either moderate acidophilic cytoplasm and small, oval or round nuclei, or weakly acidophilic or basophilic cytoplasm and moderately large vesicular nuclei. One of these types usually predominated within a case. Mesenchymal cells ranged from oval to spindle shaped, and occasionally resembled spindle cell sarcomas. Histologic examination revealed considerable amounts of fibrous and ground intracellular material. Histological patterns were influenced by epithelial cell distributions, and included tubular or tubulopapillary epithelium elements in combination with neoplastic mesenchymal elements (nine cases), or purely tubular, tubulopapillary, or sheet like epithelial structures (21 cases). Acid mucopolysaccharides were found in some of the 20 cases tested. 

Glycosaminoglycans; Index Medicus; Chemistry; Chemical Phenomena; In Vitro Techniques; Pleural Neoplasms -- pathology; Mesothelioma -- pathology; Asbestosis -- complications; Peritoneal Neoplasms -- pathology