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3093746 
Journal Article 
Renal bone disease 
Sprague, SM 
2010 
Yes 
Current Opinion in Endocrinology, Diabetes, and Obesity
ISSN: 1752-296X
EISSN: 1752-2978 
17 
6 
535-539 
WOS:000285066500007 
Purpose of review



Renal osteodystrophy is a complex disorder of bone associated with chronic kidney disease (CKD). Disturbances in mineral metabolism, which include, phosphate retention, hypocalcemia, vitamin D deficiency, and hyperparathyroidism develop early in the progression of CKD. The Kidney Disease: Improving Global Outcomes (KDIGO) has proposed a new classification system to understand the complex pathophysiology in mineral metabolism and bone disease. Understanding this pathophysiology has become especially important, as recent evidence has suggested that disordered mineral metabolism is associated with increased cardiovascular mortality and morbidity in patients with CKD.



Recent findings



This review discusses the effect of these disturbances on the skeleton and how they result in altered bone structure and turnover. The degree of hyperparathyroidism appears to affect bone turnover; however, bone biopsies appear to be the only definitive method to specifically diagnose the bone lesion.



Summary



This review will assist the clinician in the early identification of patients at risk of renal osteodystrophy. Therapeutic strategies could then be employed to prevent and correct these disturbances in mineral metabolism and, thus, avoid patient morbidity. 
adynamic bone disease; chronic kidney disease-mineral and bone disorder; hyperparathyroidism; osteitis fibrosa