US EPA

3099554 

Journal Article 

Fiber carcinogenesis: Is asbestos the only hazard? 

Stanton, MF 

1974 

Yes 

Journal of the National Cancer Institute
ISSN: 0027-8874
EISSN: 1460-2105 

HEEP/74/10389 

52 

3 

633-634 

English 

4826554 

WOS:A1974S736500001 

HEEP COPYRIGHT: BIOL ABS. Experience with asbestos showed that fibers can be subtle carcinogens that deviate from simple dose-response relationships and require long latent periods before showing carcinogenic activity. For these reasons, it would be unwise to ignore a potential problem of greater range than asbestos. unlike mose carcinogens, fibers that are a threat are sufficiently durable to remain in the tissues from which cancers are derived. Since the the carcinogenic response can be related to doses of sized fibers in experimental animals, it may be possible to equate the number and size distribution of fibers in human tissues to cancer in man. Although much has been accomplished in assessing large, protein-coated fibers in human lungs, little has been done in assessing the size distribution and total quantity of all fibers in human tissues. This would be a tedious job, but it might determine the true significance of fibers as human carcinogens. 

Carcinogens; Asbestos; 1332-21-4; Index Medicus; Structure-Activity Relationship; Environmental Exposure; Neoplasms -- chemically induced