Pentosan polysulfate: a review of its use in the relief of bladder pain or discomfort in interstitial cystitis | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

3103627

Reference Type

Journal Article

Subtype

Review

Title

Pentosan polysulfate: a review of its use in the relief of bladder pain or discomfort in interstitial cystitis

Author(s)

Anderson, VR; Perry, CM

Year

2006

Is Peer Reviewed?

Yes

Journal

Drugs
ISSN: 0012-6667
EISSN: 1179-1950

Volume

Issue

Page Numbers

821-835

Language

English

PMID

16706553

Web of Science Id

WOS:000237912100006

Abstract

Pentosan polysulfate (pentosan polysulfate sodium; ELMIRON), a heparin-like, sulfated polysaccharide, is used to manage bladder pain and discomfort in adults with interstitial cystitis (IC). Preliminary clinical models suggest that pentosan polysulfate repairs damaged glycosaminoglycan (GAG) layers lining the urothelium and in vitro data suggest it may provide an anti-inflammatory effect in patients with IC. Pentosan polysulfate shows beneficial effects in a proportion of patients with IC in terms of the improvement of a patient's overall condition and the relief of pain, and it is a generally well tolerated therapy. It is the only US FDA-approved oral treatment for the relief of bladder pain or discomfort associated with IC, and data support its role as an important option in the treatment of patients with IC.

Keywords

pentosan polysulfate; interstitial cystitis; glycosaminoglycan; pharmacodynamics; pharmacokinetics; therapeutic use