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3104048 
Journal Article 
THE TOPICAL TREATMENT OF INFUSION THROMBOPHLEBITIS WITH PENTOSAN POLYSULFATE SODIUM OINTMENT - A RANDOMIZED DOUBLE-BLIND-STUDY 
Kollar, L; Rozsos, I; Scholz, ME 
1993 
1 
Perfusion
ISSN: 0267-6591
EISSN: 1477-111X 
6 
12 
470 
WOS:A1993MT42500003 
In a 7 day randomised double-blind trial, the equivalence of efficacy of pentosan polysulfate sodium ointment (PPS ointment, 0.5%) in comparison to mucopolysaccharide ointment (MPS ointment, 0.445%) was studied in 110 adult stationary patients suffering from acute infusion thrombophlebitis in one arm. The study medication was applied three times daily. Antithrombotic and antiinflammatory efficacy were evaluated by daily monitoring of the severity of the symptoms (induration, swelling, erythema, temperature, pain) as defined by scores on a rive-stage scale. In addition, I-125-fibrinogen was injected on the day before the onset of treatment and radioactivity was measured over the inflamed veins on day 1, 3 and 7 of the treatment period. All patients concluded the treatment according to the protocol. Both ointments reduced the radioactivity in the thrombus and the global severity of symptoms to 50% after 3 days. By day 7 most patients had recovered completely from the inflammation. Thus, both ointments were equivalent in their efficacy. However, the symptom attenuation with the pentosan polysulfate sodium ointment appeared to be somewhat faster and, since this formulation is prepared from plant origin, this preparation was free from any risk of BSE infection. No adverse events were reported and the treatment was well tolerated by all patients. 
PENTOSAN POLYSULFATE SODIUM OINTMENT; MUCOPOLYSACCHARIDE OINTMENT; HEPARINOID OINTMENT; INFUSION THROMBOPHLEBITIS; DOUBLE-BLIND TRIAL; I-125-FIBRINOGEN TEST