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3116665 
Journal Article 
Solubility Measurement and Simulation of Rivaroxaban (Form I) in Solvent Mixtures from 273.15 to 323.15 K 
Sun, J; Liu, X; Fang, Z; Mao, S; Zhang, L; Rohani, S; Lu, Jie 
2016 
Yes 
Journal of Chemical and Engineering Data
ISSN: 0021-9568
EISSN: 1520-5134 
61 
1 
495-503 
WOS:000368564600057 
The solubility of active pharmaceutical ingredients in various solvents is crucial to their industrial production and the development to final formulations. In this work, the solubility of rivaroxaban (form I) in the binary solvent mixtures of 1-methyl-2-pyrrolidinone with water, methanol, ethanol, and isopropanol from 273.15 to 323.15 K has been experimentally measured. Meanwhile, the dependence of the measured solubility on the temperature as well as on the composition of solvent mixtures has been simulated by Jouyban-Acree (JA) and nonrandom two liquid (NRTL) equations, respectively. The results show that as to the solubility simulation of the studied system JA and NRTL give average relative deviations of 0.1081 and 0.1064, respectively, suggesting that both JA and NRTL can act as an efficient simulation tool for the solubility of rivaroxaban (form I) in pure and mixture solvents at various temperatures.