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3137524 
Journal Article 
NEURONAL DEVELOPMENT. Glycerophospholipid regulation of modality-specific sensory axon guidance in the spinal cord 
Guy, AT; Nagatsuka, Y; Ooashi, N; Inoue, M; Nakata, A; Greimel, P; Inoue, A; Nabetani, T; Murayama, A; Ohta, K; Ito, Y; Aoki, J; Hirabayashi, Y; Kamiguchi, H 
2015 
1 
Science
ISSN: 0036-8075
EISSN: 1095-9203 
349 
6251 
974-977 
English 
26315437 
Glycerophospholipids, the structural components of cell membranes, have not been considered to be spatial cues for intercellular signaling because of their ubiquitous distribution. We identified lyso-phosphatidyl-β-D-glucoside (LysoPtdGlc), a hydrophilic glycerophospholipid, and demonstrated its role in modality-specific repulsive guidance of spinal cord sensory axons. LysoPtdGlc is locally synthesized and released by radial glia in a patterned spatial distribution to regulate the targeting of nociceptive but not proprioceptive central axon projections. Library screening identified the G protein-coupled receptor GPR55 as a high-affinity receptor for LysoPtdGlc, and GPR55 deletion or LysoPtdGlc loss of function in vivo caused the misallocation of nociceptive axons into proprioceptive zones. These findings show that LysoPtdGlc/GPR55 is a lipid-based signaling system in glia-neuron communication for neural development.