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3146646 
Journal Article 
LB01.11: PREVALENCE OF SECONDARY HYPERTENSION IN YOUNG HYPERTENSIVE ADULTS 
Camelli, S; Bobrie, G; Postel-Vinay, N; Azizi, M; Plouin, PF; Amar, L 
2015 
1 
Journal of Hypertension
ISSN: 0263-6352
EISSN: 1473-5598 
33 Suppl 1 
e47 
English 
26102832 
OBJECTIVE: Data from referral centers suggest that approximately 10% of hypertensive patients could have secondary hypertension (2HTN). It is commonly accepted that 2HTN is more frequent in younger subjects but its prevalence is not known.

DESIGN AND METHOD: Retrospective analysis of the computerized medical records of consecutive hypertensive patients aged 18 to 40 years referred to the Georges Pompidou ESH hypertension center who underwent in-hospital work-up including renal artery duplex ultrasound or CT angiography, determination of plasma aldosterone/renin ratio and 24 h urinary metanephrine.

RESULTS: Between January 2008 and December 2013, 843 patients (52.2% women) aged 26.9 ± 6.2 years were referred to our center. 509 patients (60.4%) had a family history of hypertension and 356 (42.4%) had a body mass index exceeding 27 kg/m. BP levels were 142.0/89.2 mmHg with a median number of 1 (range 0-7) antihypertensive drugs. 250 patients (29.6%) were diagnosed with 2HTN including primary aldosteronism in 62 patients (7.4 %), fibromuscular dysplasia in 49(5.8%) and pheochromocytoma in 33 (3.9%) patients.

CONCLUSIONS: Before the age of 40, the prevalence of 2HTN is close to 30%. This high prevalence confirms the necessity of a systematic work-up for 2HTN in younger adults. Further analysis will aim to identify the phenotype based on the cause of hypertension.