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HERO ID
3152887
Reference Type
Journal Article
Subtype
Review
Title
Myeloid derived suppressor cells-An overview of combat strategies to increase immunotherapy efficacy
Author(s)
Draghiciu, O; Lubbers, J; Nijman, HW; Daemen, T
Year
2015
Volume
4
Issue
1
Page Numbers
e954829
Language
English
PMID
25949858
DOI
10.4161/21624011.2014.954829
Abstract
Myeloid-derived suppressor cells (MDSCs) contribute to tumor-mediated immune escape and negatively correlate with overall survival of cancer patients. Nowadays, a variety of methods to target MDSCs are being investigated. Based on the intervention stage of MDSCs, namely development, expansion and activation, function and turnover, these methods can be divided into: (I) prevention or differentiation to mature cells, (II) blockade of MDSC expansion and activation, (III) inhibition of MDSC suppressive activity or (IV) depletion of intratumoral MDSCs. This review describes effective mono- or multimodal-therapies that target MDSCs for the benefit of cancer treatment.
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