de Luis, DA; Pacheco, D; Aller, R; Izaola, O; Bachiller, R
BACKGROUND: Studies of the GLP-1 receptor have been directed at identifying polymorphisms in the GLP-1 receptor gene that may be a contributing factor in the pathogenesis of diabetes mellitus and cardiovascular risk factors. Nevertheless, the role of GLP-1 variants on body weight, cardiovascular risk factors and adipokines remains unclear in obese patients.
OBJECTIVE: Our aim was to analyze the effects of rs6923761 GLP-1 receptor polymorphism on body weight, cardiovascular risk factors and serum adipokine levels in morbid obese patients.
DESIGN: A sample of 175 morbid obese patients was enrolled in a prospective way. Basal fasting glucose, c-reactive protein (CRP), insulin, insulin resistance (HOMA), total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides concentration and adipokines were measured. Weights, body mass index, waist circumference, fat mass by bioimpedance and blood pressure measures were measured.
RESULTS: 87 patients (49,7%) had genotype GG and 88 (50,3%) had; GA (71 patients, 40,6%) or AA (17 patients, 9,7%) (second group). In the group with GG genotype, levels of glucose (4,4 ± 2,3 mg/dl, p < 0,05), tryglicerides (6,8 ± 4,3 mg/dl , p < 0,05), insulin (4,5 ± 2,3 UI/l , p < 0,05) and HOMA (1,5 ± 0,9 units, p < 0,05) were higher than mutant group. No differences were detected in other parameters.
CONCLUSION: Data from our study revealed an association with metabolic parameters and rs6923761. Levels of triglycerides, insulin and HOMA were higher in subjects with A alelle than non A allele subjects.