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3174095 
Journal Article 
Death or survival with major morbidity in VLBW infants born at Brazilian neonatal research network centers 
Guinsburg, R; de Almeida, MF; de Castro, JS; Silveira, RC; Caldas, JP; Fiori, HH; Do Vale, MS; Abdallah, VO; Cardoso, LE; Alves Filho, N; Moreira, ME; Acquesta, AL; Ferrari, LS; Bentlin, MR; Venzon, PS; Gonçalves Ferri, WA; Meneses, J; Diniz, EM; Zanardi, DM; Dos Santos, CN; Bandeira Duarte, JL; Rego, MA 
2016 
Journal of Maternal-Fetal & Neonatal Medicine
ISSN: 1476-7058
EISSN: 1476-4954 
29 
1005-1009 
English 
OBJECTIVE: To analyze unfavorable outcomes at hospital discharge of preterm infants born at Brazilian public university centers.

METHODS: Prospective cohort of 2646 inborn infants with gestational age 23-33 weeks and birth weight 400-1499 g, without malformations, born at 20 centers in 2012-2013. Unfavorable outcome was defined as in-hospital death or survival at hospital discharge with ≥1 major morbidities: bronchopulmonary dysplasia (BPD) at 36 corrected weeks, intraventricular hemorrhage (IVH) grades 3-4, periventricular leukomalacia (PVL) or surgically treated retinopathy of prematurity (ROP).

RESULTS: Among 2646 infants, 1390 (53%) either died or survived with major morbidities: 793 (30%) died; 497 (19%) had BPD; 358 (13%) had IVH 3-4 or PVL; and 84 (3%) had ROP. Logistic regression adjusted by center showed association of unfavorable outcome with: antenatal steroids (OR 0.70; 95%CI 0.55-0.88), C-section (0.72; 0.58-0.90), gestational age <30 (4.00; 3.16-5.07), being male (1.44; 1.19-1.75), small for gestational age (2.19; 1.72-2.78), 5th-min Apgar <7 (3.89; 2.88-5.26), temperature at NICU admission <36.0 °C (1.42; 1.15-1.76), respiratory distress syndrome (3.87; 2.99-5.01), proven late sepsis (1.33; 1.05-1.69), necrotizing enterocolitis (3.10; 2.09-4.60) and patent ductus arteriosus (1.69; 1.37-2.09).

CONCLUSIONS: More than half of the VLBW infants born at public university level 3 Brazilian hospitals either die or survive with major morbidities.