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Citation
Tags
HERO ID
3198947
Reference Type
Journal Article
Subtype
Review
Title
Redox regulation of FoxO transcription factors
Author(s)
Klotz, LO; Sánchez-Ramos, C; Prieto-Arroyo, I; Urbánek, P; Steinbrenner, H; Monsalve, M
Year
2015
Is Peer Reviewed?
1
Journal
Redox Biology
ISSN:
2213-2317
Volume
6
Page Numbers
51-72
Language
English
PMID
26184557
DOI
10.1016/j.redox.2015.06.019
Web of Science Id
WOS:000367338700006
Abstract
Transcription factors of the forkhead box, class O (FoxO) family are important regulators of the cellular stress response and promote the cellular antioxidant defense. On one hand, FoxOs stimulate the transcription of genes coding for antioxidant proteins located in different subcellular compartments, such as in mitochondria (i.e. superoxide dismutase-2, peroxiredoxins 3 and 5) and peroxisomes (catalase), as well as for antioxidant proteins found extracellularly in plasma (e.g., selenoprotein P and ceruloplasmin). On the other hand, reactive oxygen species (ROS) as well as other stressful stimuli that elicit the formation of ROS, may modulate FoxO activity at multiple levels, including posttranslational modifications of FoxOs (such as phosphorylation and acetylation), interaction with coregulators, alterations in FoxO subcellular localization, protein synthesis and stability. Moreover, transcriptional and posttranscriptional control of the expression of genes coding for FoxOs is sensitive to ROS. Here, we review these aspects of FoxO biology focusing on redox regulation of FoxO signaling, and with emphasis on the interplay between ROS and FoxOs under various physiological and pathophysiological conditions. Of particular interest are the dual role played by FoxOs in cancer development and their key role in whole body nutrient homeostasis, modulating metabolic adaptations and/or disturbances in response to low vs. high nutrient intake. Examples discussed here include calorie restriction and starvation as well as adipogenesis, obesity and type 2 diabetes.
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