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3201833 
Journal Article 
Protective Effect of 4-(3, 4-Dihydroxyphenyl)-3-buten-2-one from Phellinus linteus on Naproxen-induced Gastric Antral Ulcers in Rats 
Kim, JH; Kwon, HJ; Kim, BW 
2016 
Yes 
Journal of Microbiology and Biotechnology
ISSN: 1017-7825
EISSN: 1738-8872 
English 
26767575 
The present study was investigated the protective effect of naturally purified 4-(3, 4-dihydroxyphenyl)-3-buten-2-one (DHP) from Phellinus linteus against naproxen-induced gastric antral ulcers in rats. To verify the protective effect of DHP on naproxen-induced gastric antral ulcers, various doses (1, 5, and 10 µg/kg) of DHP were pretreated for 3 days, and then gastric damage was caused by 80 mg/kg naproxen applied for 3 days. DHP prevented naproxen-induced gastric antral ulcers in a dose-dependent manner. Especially, 10 µg/kg DHP showed the best protective effect against naproxen-induced gastric antral ulcers. Also, DHP significantly attenuated naproxen-induced lipid peroxide level in gastric mucosa and increased activities of radical scavenging enzymes, such as superoxide dismutase (SOD), catalase, and glutathione peroxidase in a dose-dependent manner. A histological examination clearly demonstrated that the gastric antral ulcer induced by naproxen nearly disappeared after the pretreatment of DHP. These results suggest that DHP can inhibit naproxen-induced gastric antral ulcers through prevention of lipid peroxidation and activation of radical scavenging enzymes.