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Citation
Tags
HERO ID
3202596
Reference Type
Journal Article
Title
Homotypic Dengue Virus Reinfections in Nicaraguan Children
Author(s)
Waggoner, JJ; Balmaseda, A; Gresh, L; Sahoo, MK; Montoya, M; Wang, C; Abeynayake, J; Kuan, G; Pinsky, BA; Harris, E
Year
2016
Is Peer Reviewed?
Yes
Journal
Journal of Infectious Diseases
ISSN:
0022-1899
EISSN:
1537-6613
Language
English
PMID
26984144
DOI
10.1093/infdis/jiw099
Abstract
BACKGROUND:
Infection with any of the 4 related dengue virus serotypes (DENV-1-4) is thought to result in lifelong immunity to homotypic reinfection (ie, reinfection with the same serotype).
METHODS:
Archived serum samples collected as part of an ongoing pediatric dengue cohort study in Nicaragua were tested for DENV by real-time reverse transcription polymerase chain reaction. Samples were collected from 2892 children who presented with an acute febrile illness clinically attributed to a non-DENV cause (hereafter, "C cases"). Test results were added to a database of previously identified symptomatic dengue cases in the cohort to identify repeat infections.
RESULTS:
Four patients with homotypic DENV reinfections were identified and confirmed among 29 repeat DENV infections (13.8%) with serotype confirmation. Homotypic reinfections with DENV-1, DENV-2, and DENV-3 occurred 325-621 days after the initial infection. Each patient experienced 1 symptomatic dengue case and 1 DENV-positive C case, and 2 patients presented with symptomatic dengue during their second infection. These DENV-positive C cases did not elicit long-lived humoral immune responses, despite viremia levels of up to 6.44 log10copies per mL of serum.
CONCLUSIONS:
We describe the first set of virologically confirmed homotypic DENV reinfections. Such cases challenge the current understanding of DENV immunity and have important implications for modeling DENV transmission.
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