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3203111 
Journal Article 
The Scavenging of DPPH, Galvinoxyl and ABTS Radicals by Imine Analogs of Resveratrol 
Kotora, P; Šeršeň, F; Filo, J; Loos, D; Gregáň, J; Gregáň, F 
2016 
1 
Molecules
ISSN: 1420-3049 
21 
1 
English 
26805801 
Resveratrol (3,5,4'-trihydroxystilbene) is a phytoalexin produced by plants. Resveratrol is known for its anti-cancer, antiviral and antioxidant properties. We prepared imine analogs of resveratrol ((hydroxyphenyliminomethyl)phenols) and tested their antioxidant activity. All prepared resveratrol analogs were able to scavenge 2,2-diphenyl-1-picrylhydrazyl (DPPH), galvinoxyl radical (GOR) and 2,2'-azino-bis(3-ethylbenzothiazoline)-6-sulphonic acid (ABTS) radicals. The antioxidant activity efficiency correlated with the number and position of hydroxyl groups. The most effective antioxidants were resveratrol analogs containing three hydroxyl groups in the benzylidene part of their molecules. These results provide new insights into the relationship between the chemical structure and biological activity of resveratrol analogs.