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HERO ID
3206975
Reference Type
Journal Article
Title
Neosartoryadins A and B, Fumiquinazoline Alkaloids from a Mangrove-Derived Fungus Neosartorya udagawae HDN13-313
Author(s)
Yu, G; Zhou, G; Zhu, M; Wang, W; Zhu, T; Gu, Q; Li, D
Year
2016
Is Peer Reviewed?
1
Journal
Organic Letters
ISSN:
1523-7060
EISSN:
1523-7052
Volume
18
Issue
2
Page Numbers
244-247
Language
English
PMID
26713369
DOI
10.1021/acs.orglett.5b02964
Abstract
Neosartoryadins A (1) and B (2), both with a unique 6/6/6/5 quinazoline ring system connected directly to a 6/5/5 imidazoindolone ring, together with three biogenetically related compounds 3-5, were isolated from the endophytic fungus Neosartorya udagawae HDN13-313. The absolute configurations of new compounds 1-4 were established. Compounds 1 and 2 displayed anti-influenza virus A (H1N1) activities with IC50 values of 66 and 58 μM, respectively (ribavirin as positive control, IC50 = 94 μM).
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