Health & Environmental Research Online (HERO)


Print Feedback Export to File
3207671 
Journal Article 
Adenoid cystic carcinoma of the lacrimal gland 
Sanders, JC; Mendenhall, WM; Werning, JW 
2016 
Yes 
American Journal of Otolaryngology
ISSN: 0196-0709
EISSN: 1532-818X 
37 
2 
144-147 
English 
26954871 
PURPOSE: This is a retrospective analysis of the 50-year University of Florida experience treating adenoid cystic carcinoma of the lacrimal gland with radiation therapy.

MATERIALS AND METHODS: Between 1965 and 2015, 8 patients with adenoid cystic carcinoma of the lacrimal gland received radiation therapy with curative intent. Four patients received postoperative radiation therapy and 4 received definitive radiation therapy alone. The median follow-up was 3.3years (range, 0.3 to 11.2years).

RESULTS: All 4 patients who received postoperative radiation therapy received 74.4Gy. The 4 patients who received radiation therapy alone received a median dose of 72.3Gy (range, 70.0 to 74.4Gy). The overall survival rates at 5 and 10years were 25% and 13%, respectively. The cause-specific survival rates at 5 and 10years were 29% and 14%, respectively. The local control and freedom from metastases rates at 5 and 10years were both 43%. Local recurrences occurred in 50% of patients, and distant metastatic disease occurred in 38% of patients. No patients experienced acute complications of treatment that warranted a treatment break. Two patients experienced bone exposure as late complications of treatment.

CONCLUSIONS: The results of this study illustrate the propensity for adenoid cystic carcinoma of the lacrimal gland to recur both locally and with distant metastases despite aggressive local treatment measures. This study also demonstrates the relatively poor outcomes for individuals with this type of tumor.