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Citation
Tags
HERO ID
3208253
Reference Type
Journal Article
Title
Liver transplantation after ex vivo normothermic machine preservation: A Phase 1 (first-in-man) clinical trial
Author(s)
Ravikumar, R; Jassem, W; Mergental, H; Heaton, N; Mirza, D; Perera, MT; Quaglia, A; Holroyd, D; Vogel, T; Coussios, CC; Friend, PJ
Year
2016
Is Peer Reviewed?
Yes
Journal
American Journal of Transplantation
ISSN:
1600-6135
EISSN:
1600-6143
Volume
16
Issue
6
Page Numbers
1779-1787
Language
English
PMID
26752191
DOI
10.1111/ajt.13708
Abstract
The number of donor organs suitable for liver transplantation is restricted by cold preservation and ischemia-reperfusion injury (IRI). We present the first patients transplanted using a normothermic machine perfusion (NMP) device that transports and stores an organ in a fully functioning state at 37°C. In this Phase 1 trial, organs were retrieved using standard techniques, attached to the perfusion device at the donor hospital and transported to the implanting centre in a functioning state. NMP livers were matched 1:2 to cold-stored livers. 20 patients underwent liver transplantation after NMP. Median NMP time was 9·3 (3·5 - 18·5) hours vs median CIT of 8·9 (4·2 - 11·4) hours. 30-day graft survival was similar (100% NMP vs. 97·5% Control, p=1·00). Median peak AST in the first 7 days was significantly lower in the NMP group (417 IU (84 - 4681)) vs (902 IU (218 - 8786), p=0·03). This first report of liver transplantation using NMP-preserved livers demonstrates the safety and feasibility of using this technology from retrieval to transplantation, including transportation. NMP may be valuable in increasing the number of donor livers improving the function of transplantable organs. This article is protected by copyright. All rights reserved.
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