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HERO ID
3234878
Reference Type
Journal Article
Title
Ethyl acetate extract from Angelica Dahuricae Radix inhibits lipopolysaccharide-induced production of nitric oxide, prostaglandin E-2 and tumor necrosis factor-alpha via mitogen-activated protein kinases and nuclear factor-kappa B in macrophages
Author(s)
Kang, OkHwa; Lee, GoH; Choi, HJ; Park, PilS; Chae, HeeS; Jeong, SIl; Kim, YC; Sohn, DH; Park, H; Lee, JHwa; Kwon, DY
Year
2007
Is Peer Reviewed?
1
Journal
Pharmacological Research
ISSN:
1043-6618
EISSN:
1096-1186
Volume
55
Issue
4
Page Numbers
263-270
DOI
10.1016/j.phrs.2006.12.001
Web of Science Id
WOS:000246283000003
Abstract
Angelica dahurica (Umbelliferae) has been used to treat headache of common cold, supraorbital neuralgia, painful swelling on the body, nasal stuffiness, leukorrhea and arthralgia due to wind-dampness in Korean traditional medicine. It is also claimed to be effective in the treatment of acne, erythema, headache, toothache, sinusitis, colds and flu. The present study focused whether the ethyl acetate extract from Angelica Dahuricae Radix (EAAD) inhibits production of nitric oxide (NO), prostaglandin E-2 (PGE(2)) and tumor necrosis factor (TNF)-alpha, as well as expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), nuclear factor-KB (NF-KB) and mitogen-activated protein kinases (MAPKs) in lipopolysaccharide (LPS)-stimulated macrophages. EAAD inhibited LPS-induced NO, PGE(2) and TNF-alpha production as well as expression of iNOS and COX-2 in RAW 264.7 cells. EAAD inhibited LPS-induced TNF-alpha production in THP-1 cells. Furthermore, EAAD suppressed LPS-induced phosphorylation of p38 MAPK and extracellular-signal regulated kinases 1/2 (ERKI/2), I-kappa B alpha degradation, and NF-kappa B activation in RAW 264.7 cells. These results suggest that EAAD has the inhibitory effects on LPS-induced TNF-alpha, NO and PGE(2) production, and expression of iNOS and COX-2 in macrophage through blockade in the phosphorylation of MAPKs, following I-kappa B alpha degradation and NF-kappa B activation. (C) 2006 Elsevier Ltd. All rights reserved.
Keywords
Angelica Dahuricae Radix; inducible nitric oxide synthase; cyclooxygenase-2; mitogen-activated protein kinase (MAPK); nuclear factor-kappa B
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