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3239221 
Journal Article 
Cardiovascular tests: Use & limits of biochemical markers - Therapeutic measurements of ADMA involved in cardiovascular disorders 
Smith, CL; Vallance, P 
2005 
Yes 
Current Pharmaceutical Design
ISSN: 1381-6128
EISSN: 1873-4286 
11 
17 
2177-2185 
WOS:000229762900005 
Asymmetric dimethylarginine (ADMA) is an endogenously occurring methylarginine that inhibits nitric oxide synthesis. Plasma levels of methylarginines increase in renal failure and certain cardiovascular pathologies, and in patients with end stage renal failure the level of ADMA predicts the risk of cardiovascular events and overall mortality. The object of this review is to describe the mechanisms of ADMA synthesis, metabolism and uptake and to outline techniques for measuring ADMA and the pathological states in which ADMA levels are altered.