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3241309 
Book/Book Chapter 
Polymer Nanoparticles 
Lu, XYun; Wu, DaoC; Li, ZJun; Chen, GuoQ 
2011 
Progress in Molecular Biology and Translational Science 
104 
299-323 
WOS:000299296000007 
Over the past few decades, interest in designing and
developing polymeric nanoparticles has undergone considerable explosion. Indeed, these
nanoparticulated polymer-based systems provide potential solution to improve therapeutic efficacy
and diagnosis sensitivity. In this chapter, general properties, production, and characterization
of polymer nanoparticles are introduced. Specifically, the development and application of
polyhydroxyalkanoate (PHA)-based nanoparticles are emphasized because of the good biocompatible,
biodegradable properties, as well as their mechanical flexibility. These PHAs nanoparticles can
serve as targeting drug delivery carriers and protein purification and immobilization matrices.
The perspective outlook in the last section highlights the future application of polymer
nanoparticles in translational science.