US EPA

3243696 

Journal Article 

Oxidative DNA Damage and Carcinogenesis 

Jiang, Li; Toyokuni, S 

2011 

Yes 

Frontiers of Gastrointestinal Research
ISSN: 0302-0665
EISSN: 1662-3754 

Frontiers of Gastrointestinal Research 

29 

55-63 

WOS:000286842200005 

Carcinogenesis follows multi-step processes involving both
genetic alteration and increased cell proliferation. Oxidative stress can occur via
overproduction of reactive oxygen and nitrogen species through either endogenous or exogenous
insults. Oxidative stress is always associated with inflammation, radiation, reperfusion, and
iron overload. Epidemiological observations have shown that oxidative stress is one of the major
pathologic mechanisms for cancer, the top-ranked cause of human mortality worldwide. During
carcinogenesis, the unregulated or prolonged production of cellular oxidants has been linked to
mutation through generation of oxidative DNA damage. Furthermore, signal transduction pathways
are activated by reactive species, and they lead to the transcription of genes involved in
cellular growth regulatory and stress protection pathways. This review examines the involvement
of oxidative stress in the carcinogenic process starting from its history, and presents future
perspectives. Copyright (C) 2011 S. Karger AG, Basel