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3254988 
Journal Article 
TOXICOLOGY INVESTIGATIONS WITH CELL-CULTURE SYSTEMS 
Stammati, AP; Silano, V; Zucco, F 
1981 
1 
Toxicology
ISSN: 0300-483X
EISSN: 1879-3185 
20 
2-3 
91-153 
WOS:A1981LV68800001 
PESTAB. Cell culture systems most frequently used in toxicology investigations are reviewed, with emphasis on their effectiveness in assessing the toxic potential of chemicals. Included in the discussion are metabolic studies and general and specific toxicology investigations. Cell culture techniques are important because toxicology investigations on animals are costly, time-consuming, and have other limitations. The various cell culture systems (primary culture, cell lines, or cell strains) are described, and some of the cell types used in toxicity investigations are listed. Some of the effects of pesticides on fibroblast and epithelial cells are tabulated. A description of cell-specific toxicology investigations includes several pesticides (carbaryl, lindane, propham, DDT, methyl parathion, paraquat, paraoxon) as examples. Metabolic investigations are also discussed.