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3283639 
Journal Article 
Analysing and interpreting DNA methylation data 
Bock, C 
2012 
1 
Nature Reviews. Genetics
ISSN: 1471-0056
EISSN: 1471-0064 
13 
10 
705-719 
WOS:000309059200010 
DNA methylation is an epigenetic mark that has suspected regulatory roles in a broad range of biological processes and diseases. The technology is now available for studying DNA methylation genome-wide, at a high resolution and in a large number of samples. This Review discusses relevant concepts, computational methods and software tools for analysing and interpreting DNA methylation data. It focuses not only on the bioinformatic challenges of large epigenome-mapping projects and epigenome-wide association studies but also highlights software tools that make genome-wide DNA methylation mapping more accessible for laboratories with limited bioinformatics experience.