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HERO ID
3312981
Reference Type
Journal Article
Title
Excavating relics of DNA methylation changes during the development of neoplasia
Author(s)
Hsiao, ShuH; Huang, TimHM; Leu, YuWei
Year
2009
Is Peer Reviewed?
1
Journal
Seminars in Cancer Biology
ISSN:
1044-579X
EISSN:
1096-3650
Volume
19
Issue
3
Page Numbers
198-208
DOI
10.1016/j.semcancer.2009.02.015
Web of Science Id
WOS:000265729400010
Abstract
Epigenetic events like DNA methylation are known to regulate gene expression, and dysregulation of these events is associated with neoplastic proliferation. Here, we provide a step-by-step review of the approach that has gradually developed to identify critical DNA methylation during neoplasia. DNA methylation has first been tightly linked to the regulation of gene expression and functions. Next, the clinical importance of such DNA methylation has been probed by inducing loss of the maintenance of normal DNA methylation, which has been found to trigger onset of disease. Methylation changes can be signal-specific and lineage-specific, providing a record what cells have encountered and what they have become. Comparison of methylation associated with normal cellular differentiation and abnormal cell fate changes is expected to uncover critical methylation changes. We also propose a specific scheme that can be used to excavate critical DNA methylation associated with cell evolution. (C) 2009 Published by Elsevier Ltd.
Keywords
Epigenetics; DNA methylation; Cancer and cell signaling
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