Health & Environmental Research Online (HERO)


Print Feedback Export to File
3335479 
Journal Article 
TETonic shift: biological roles of TET proteins in DNA demethylation and transcription 
Pastor, WA; Aravind, L; Rao, A 
2013 
1 
Nature Reviews. Molecular Cell Biology
ISSN: 1471-0072
EISSN: 1471-0080 
14 
6 
341-356 
WOS:000319462200011 
In many organisms, the methylation of cytosine in DNA has a key role in silencing 'parasitic' DNA elements, regulating transcription and establishing cellular identity. The recent discovery that ten-eleven translocation (TET) proteins are 5-methylcytosine oxidases has provided several chemically plausible pathways for the reversal of DNA methylation, thus triggering a paradigm shift in our understanding of how changes in DNA methylation are coupled to cell differentiation, embryonic development and cancer.