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3339920 
Journal Article 
Nanoparticle detection by microfluidic Resistive Pulse Sensor with a submicron sensing gate and dual detecting channels-two stage differential amplifier 
Song, Y; Zhang, H; Chon, CHee; Pan, X; Li, D 
2011 
1 
Sensors and Actuators B: Chemical
ISSN: 0925-4005
EISSN: 1873-3077 
155 
2 
930-936 
WOS:000291774100072 
This paper reports a method of detecting nanoparticles using a microfluidic differential Resistive Pulse Sensor (RPS). Using a single microfluidic channel with two detecting arm channels placed at the two ends of the sensing section, the microfluidic differential RPS can achieve a high sensitivity allowing the detection of nanometer size particles. Two-stage differential amplification is used to further increase the signal-to-noise ratio. This method is able to detect nanoparticles of 490 nm and 220 nm on a microfluidic Chip. The method described in this paper is simple and can be applied to develop a compact device without the need of bulky, sophisticated electronic instruments or complicated nano-fabrication processes. (C) 2011 Elsevier B.V. All rights reserved. 
Lab-on-chip; Nanoparticle detection; Resistive Pulse Sensor; Differential amplification