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HERO ID
3343817
Reference Type
Journal Article
Title
Sperm DNA damage caused by oxidative stress: modifiable clinical, lifestyle and nutritional factors in male infertility
Author(s)
Wright, C; Milne, S; Leeson, H
Year
2014
Is Peer Reviewed?
1
Journal
Reproductive BioMedicine Online
ISSN:
1472-6483
EISSN:
1472-6491
Volume
28
Issue
6
Page Numbers
684-703
DOI
10.1016/j.rbmo.2014.02.004
Web of Science Id
WOS:000338862000004
Abstract
DNA fragmentation is an important factor in the aetiology of male infertility. However, it is still underevaluated and its inclusion in routine semen analysis is debated. DNA fragmentation has been shown to be a robust indicator of fertility potential, more so than conventional semen parameters. Men with high DNA fragmentation levels have significantly lower odds of conceiving, naturally or through procedures such as intrauterine insemination and IVF. Couples may be counselled to proceed directly to intracytoplasmic sperm injection as it is more successful in this group, avoiding costly procedures, recurrent failures or pregnancy losses; however, this treatment is not without limitations or risks. Ideally DNA fragmentation should be minimized where possible. Oxidative stress is the major cause of DNA fragmentation in spermatozoa. Endogenous and exogenous factors that contribute to oxidative stress are discussed, and in many cases are shown to be easily modifiable. Antioxidants play a protective role, although a delicate balance of reduction and oxidation is required for essential functions, including fertilization. Reducing oxidative stress may improve a couple's chances of conception either naturally or via assisted reproduction. Sources of oxidative stress therefore should be thoroughly examined in men with high levels of DNA fragmentation and modified where possible. (C) 2014, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
Keywords
antioxidants; DNA fragmentation; ICSI; male infertility; oxidative stress; ROS
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