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3371217 
Journal Article 
Plasma Blood Coagulation Without Involving the Activation of Platelets and Coagulation Factors 
Ikehara, S; Sakakita, H; Ishikawa, K; Akimoto, Y; Yamaguchi, T; Yamagishi, M; Kim, J; Ueda, M; Ikeda, JunI; Nakanishi, H; Shimizu, N; Hori, M; Ikehara, Y 
2015 
1 
Plasma Processes and Polymers
ISSN: 1612-8850
EISSN: 1612-8869 
12 
12 
1348-1353 
WOS:000368449900004 
The objective of this study is to determine whether there is a pathway different from the natural blood coagulation process involved in the plasma-induced activation of platelets and coagulation factors. Plasma treatment of bleeding wounds generated glomerular structures, which could be detected in high-magnification scanning electron microscopy images, and plasma flares produced aggregation on the surface of solutions containing bovine serum albumin, ovalbumin (OVA), or similar protein material. Ultramicroscopic analysis of the plasma-generated aggregation of OVA indicated a possible mechanism to explain the particle formation and fusion as a monotonous solid appearance. This study suggests that plasma coagulation involves aggregations of materials in blood in addition to the activation of platelets and coagulation factors by plasma treatment. 
coagulation; hemostasis; nonthermal plasma; protein aggregation