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3378313 
Journal Article 
Levels of polycyclic aromatic hydrocarbons in maternal serum and risk of neural tube defects in offspring 
Wang, B; Jin, L; Ren, A; Yuan, Y; Liu, J; Li, Z; Zhang, L; Yi, D; Wang, LL; Zhang, Y; Wang, X; Tao, S; Finnell, RH 
2015 
1 
Environmental Science & Technology
ISSN: 0013-936X
EISSN: 1520-5851 
49 
1 
588-596 
English 
25488567 
WOS:000347589300068 
has erratum 3378332 Correction to
Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental pollutants, and have been reported to be a risk factor for human neural tube defects (NTDs). We investigated the relationship between PAH concentrations in maternal serum and NTD risk in offspring using a case-control study design, and explored the link between PAH concentrations to household energy usage characteristics and life styles. One hundred and seventeen women who had NTD-affected pregnancies (cases) and 121 women who delivered healthy infants (controls) were recruited in Northern China. Maternal blood samples were collected at pregnancy termination or at delivery. Twenty-seven PAHs were measured by gas chromatography-mass spectrometry. The concentrations of 13 individual PAHs detected were significantly higher in the cases than in the controls. Clear dose-response relationships between concentrations of most individual PAHs and the risk of total NTDs or subtypes were observed, even when potential covariates were adjusted for. High-molecular-weight PAHs (H-PAHs) showed higher risk than low-molecular-weight PAHs (L-PAHs). No associations between PAH concentrations and indoor life styles and energy usage characteristics were observed. It was concluded that maternal exposure to PAHs was associated with an increased risk of NTDs, and H-PAHs overall posed a higher risk for NTDs than L-PAHs. 
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