US EPA

34054 

Journal Article 

Abstract 

Histopathologic effects of nitrogen dioxide exposure and heat stress in cynomolgus monkeys 

Busey, WM; Coate, WB; Badger, DW 

1974 

1 

Toxicology and Applied Pharmacology
ISSN: 0041-008X
EISSN: 1096-0333 

29 

1 

130 

English 

WOS:A1974T653800146 

is part of a larger document 3378179 Abstracts of papers for the Thirteenth Annual Meeting of the Society of Toxicology, Washington, D.C. March 10–14, 1974

Histopathologic studies were conducted on the lungs from male cynomolgus monkeys exposed continuously for 90 days, with and without heat stress, to 5 and 10 ppm of nitrogen dioxide. Similar studies were conducted on the lungs from air exposed monkeys with and without heat stress. Nitrogen dioxide-related microscopic alterations were seen in the respiratory bronchioles, alveolar ducts and adjacent interalveolar septa. These alterations were characterized by an interstitial infiltration of mononuclear macrophages, lymphocytes and occasionally polymorphonuclear leucocytes. Bronchiolar epithelial hyperplasia was also frequently seen in the monkeys exposed to both 5 and 10 ppm of nitrogen dioxide. Granular pneumonocyte hyperplasia was occasionally seen in alveoli adjacent to affected bronchioles. Focal pulmonary edema was present in the lungs from some monkeys exposed to 10 ppm of nitrogen dioxide. No microscopic morphological effect of heat stress was seen in the lungs from either the nitrogen dioxide-exposed or control monkeys. 

Thirteenth Annual Meeting of the Society of Toxicology 

Washington, DC 

March 10–14, 1974